We have an attractive, ERC funded postdoc position available, to study how metabolism shapes drug tolerance. We study the problem in C. albicans, and have sequenced and characterized a huge collection of yeast isolates for this purpose. Our favorite technology is mass spectrometry based proteomics, and we are adressing this problem using system-level approaches.

Cellular and molecular biology of axonal transport related to neurotransmission. Use of biosensors, videomicroscopy, microfluidic devices, and mice. Please contact Frédéric Saudou directly.

We study the dynamic regulation of proteolytic pathways that integrate environmental and physiological changes to identify protein degradation networks that protect the proteome of the organism. Your profile:

• A Ph.D. in biology, biochemistry or a related field and experience in organismal biology are required
• Strong interest in protein quality control and aging research
• Highly intrinsically motivated, creative, dedicated, and critical thinker
• Ability to clearly communicate research results to other lab members
• Excellent oral and written communication skills in English
• Team player who can work independently in an international team
• Proactive, flexible, and problem-solving attitude

Your tasks:

• Design and lead research projects to elucidate mechanisms of protein quality control and degradation of damaged proteins
• Advise and mentor undergraduate, graduate, and PhD students

The brain surface is connected to the periphery by the meninges, previously thought to be an inert tissue. Revolutionizing findings reveal that the meninges are populated by resident immune sentinels, crucial for neuronal function, tissue homeostasis and protection, and thus involved in neurological diseases. Meningeal macrophages are fascinating cells, pivotal in CNS function and dysfunction, though their properties remain largely unknown. This project aims to explore how these macrophages support neuronal functions and how that affects mouse cognition. The research will utilize multiparametric flow cytometry, single-cell transcriptomics, CRISPR-Cas9, stereotactic injections, and intravital imaging in wild-type and transgenic mice. The team offers a dynamic, well-equipped environment near Calanques National Park, France. Applicants with a PhD in immunology or neuroscience and should contact .

The main goal of the project is to understand the establishment of endosymbiosis by identifying and characterizing novel protist-endosymbiont systems at intermediate stages of endosymbiosis. We will screen various freshwater environments for such interactions and isolate and identify the partners using microscopic and genetic methods. The organisms in the intermediate stages of endosymbiosis will be studied at the level of genome evolution and regulation of gene expression that accompanies the endosymbiotic interaction. We will also study the ultrastructure of the studied cells, which – together with the genetic information – will reveal the nature of the studied systems. The ideal post-doctoral candidate will have a strong interest in evolutionary biology and microbial eukaryotes (protists). Experience in laboratory work and/or sampling and research experience in culturing microorganisms and microscopy and/or bioinformatics and genomic analysis is required.

The heterochromatin factor KAP1 plays important roles in telomere protection, gene repression and DNA repair. By following-up on recent findings from our group we will aim to increase our understanding of how KAP1 contributes to genome stability maintenance. We will study how KAP1 activity is controlled by novel regulators of KAP1 that we recently identified in genetic screens. Moreover, we will study how cancer cells benefit from KAP1 overexpression and how this may potentially be exploited therapeutically. We are looking for an ambitious and enthusiastic PhD candidate with a strong commitment to science and solid background in molecular biology and cell biology. The candidate should be creative, highly self-motivated, capable of independent thinking, have a problem-solving attitude and be a very good experimentalist. Good communication skills (oral and written) and ability to work together with others in an international team are essential.

Two postdoctoral positions are available in the Alimonti lab to be part of an ongoing effort to elucidate the role of gut and intratumoral microbiota in cancer. The successful candidates will use and implement an innovative proprietary microfluidic platform to identify bacterial products with anti-cancer properties, apply different approaches (10X genomics single cell, metagenomics, proteomics, metabolomics, drug screenings) and generate novel mouse models to understand how bacteria and fungi control prostate tumor development. We offer a vibrant environment of scientists. We look for highly motivated candidates with outstanding basic and cancer biology and proven microbiology expertise. Experience with in vivo cancer models is mandatory, bioinformatics knowledge is a plus. We require at least one first-author original research publication in a high IF journal, the ability to work independently, interact with colleagues with different backgrounds, and establish relevant collaborations.