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Defying the virus

Across the world, scientists and clinicians have combined in extraordinary efforts to help fight the COVID-19 pandemic. Three members of the EMBO community tell Kathy Weston how they and their colleagues have risen to this scientific challenge.

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“Mini brain” organoids show potential for SARS-CoV2 to cause neurodegenerative- disease-like effects

New research published yesterday in The EMBO Journal reports that the SARS-CoV-2 coronavirus can target human neurons with the potential to cause disease of the central nervous system (CNS). The research showed that the virus can enter tiny laboratory-developed 3D structures called brain organoids that replicate key aspects of the human brain and induce pathological effects similar to early stages of diseases of the CNS such as Alzheimer’s.

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